Document Detail


p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas.
MedLine Citation:
PMID:  8666369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent molecular biological studies have shown evidence for a distinct pathogenesis of pilocytic astrocytomas based on alterations other than mutations of the tumor suppressor gene p53. To prove these data, the authors screened a series of 42 astrocytic human brain tumors with a relatively high proportion (16.6%) of the pilocytic variant for the presence of p53 mutations, using the polymerase chain reaction (PCR) and single-strand conformation polymorphism (SSCP) analysis, followed by DNA sequencing. Mutations were found in one of seven (14.3%) pilocytic astrocytomas, in one of 18 (5.6%) low grade astrocytomas, and in one of four (25%) anaplastic astrocytomas, but in none of 13 glioblastomas. Sites of missense mutations were in exon 8 (codons 281 and 282), and exon 5 (codon 151). Silent mutation was found in exon 9 (codon 324), which was related to pilocytic astrocytoma. This is, to the authors' knowledge, the first report that shows a p53 mutation in pilocytic astrocytomas. However, the p53 mutation was only found in one of seven tumors of this entity and was a silent mutation, which does not lead to change of amino acids. Thus, the significance of this alteration for the development of this special tumor type seems to be low. Nevertheless, it may be a sign of genetic instability and is thus suggested to be of certain pathogenetic relevance. The p53 findings concerning the other tumors are in accordance with the view of p53 gene mutations to be early events in astrocytoma formation.
Authors:
S Patt; H Gries; M Giraldo; J Cervos-Navarro; H Martin; W Jänisch; J Brockmöller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human pathology     Volume:  27     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-9     Citation Subset:  IM    
Affiliation:
Institute of Neuropathology, Free University of Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Astrocytoma / genetics*,  pathology
Base Sequence
Brain Neoplasms / genetics*,  pathology
Child
Child, Preschool
Female
Genes, p53*
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation*
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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