Document Detail

p53 gene mutations are rare in human papillomavirus-associated colon cancer.
MedLine Citation:
PMID:  14534749     Owner:  NLM     Status:  MEDLINE    
Recent studies suggest that infection with high risk human papillomavirus (HPV) is a common event in colon tumors. Infection by oncogenic HPV may result in functional inactivation of the p53 protein in absence of mutations. Thus far no studies have been made to examine the frequency of p53 mutations in HPV-associated colon cancer. The purpose of this study was to investigate the interrelationship between p53 mutations and HPV infection. The 'hot-spot' region of the p53 gene for mutations was analyzed by PCR-SSCP and direct sequencing in HPV-positive tumor samples. Only 2 mutations were identified in 56 samples. This rate was much lower than reported for sporadic colon tumors. Our results indicate an inverse relationship between p53 mutations and HPV infection and suggest that p53 inactivation caused by HPV infection may play a role in the pathogenesis of colon cancer.
Nur Buyru; Metin Budak; Hulya Yazici; Nejat Dalay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  10     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-10-09     Completed Date:  2004-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2089-92     Citation Subset:  IM    
Molecular Oncology and Hepatopathology Research and Application Cencer, Cerrahpasa Medical Faculty, Istanbul, Turkey.
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MeSH Terms
Colonic Neoplasms / genetics*,  virology*
DNA Mutational Analysis
DNA Primers / chemistry
Genes, p53*
Papillomaviridae / genetics*
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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