| p53 and follow-up of colorectal adenocarcinomas. | |
| | |
MedLine Citation:
|
PMID: 9690377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Circulating p53 antibodies (ELISA method), p53 genetic alterations (SSCP), and protein overexpression (immunohistochemistry) were studied in 41 patients with colorectal adenocarcinomas and 10 control patients. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19.9 (CA 19-9) were evaluated in parallel. Ten patients with p53 antibodies and p53 overexpression were selected. Tumor DNA extracts from these 10 patients were analyzed by SSCP. Of all 41 patients, 10 (24%) showed significant levels of p53 antibodies, and p53 accumulation was detected in 20 (48%) patients. In six patients, p53 antibody concentrations decreased rapidly after surgery; in two patients, these levels returned to normal values. Of the 10 selected tumors, eight revealed TP53 gene mutations. Only two patients with high values of both CEA and CA 19-9 developed p53 antibodies. In conclusion, beside classical tumor markers, circulating p53 antibodies may be considered as additional markers for the management of patients with colorectal adenocarcinomas. |
| | |
Authors:
|
A Polge; J F Bourgaux; E Bancel; C Pignodel; J C Boyer; S Poirey; B M de Bornier; J L Balmes; J P Bali |
Related Documents
:
|
698917 - Carcinoembryonic antigen in patients with breast cancer: an adjunctive tool to monitor ... 18228647 - Evolution of anticoagulant and antiplatelet therapy: benefits and risks of contemporary... 18280057 - Observations on real-time prostate gland motion using electromagnetic tracking. 12845757 - Value of quantitative analysis of serum ctnt in diagnosis of cardiac disease and myocar... 16445727 - Stroke volume and mitral annular velocities: insights from uremic patients with signifi... 16905577 - Differential effect of methotrexate on the increased ccr2 density on circulating cd4 t ... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 43 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1998 Jul |
Date Detail:
|
Created Date: 1998-08-19 Completed Date: 1998-08-19 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1434-42 Citation Subset: AIM; IM |
Affiliation:
|
Unité Fonctionnelle d'Exploration de la Fibre Lisse, Service d'Hepato-Gastroenterologie, Laboratoire d'Anatomie-Pathologie, CHU, Nîmes, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
diagnosis*,
genetics,
immunology Aged Aged, 80 and over Case-Control Studies Colorectal Neoplasms / diagnosis*, genetics, immunology DNA, Neoplasm / genetics Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Genes, p53 / genetics Humans Male Middle Aged Mutation Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Tumor Markers, Biological / blood* Tumor Suppressor Protein p53 / genetics, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Neoplasm; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Abnormal intragastric distribution of a liquid nutrient meal in patients with diabetes mellitus.
Next Document: Colitis and colon cancer in cotton-top tamarins (Saguinus oedipus oedipus) living wild in their natu...