Document Detail


p53-dependent pathways in neurite outgrowth and axonal regeneration.
MedLine Citation:
PMID:  22271139     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The tumor suppressor p53 is a multifunctional sensor of a number of cellular signals and pathways essential for cell biology, including DNA damage, cell cycle regulation, apoptosis, angiogenesis and cell metabolism. In the last few years, a novel role for p53 in neurobiology has emerged, which includes a role in the regulation of neurite outgrowth and axonal regeneration. p53 integrates a number of extracellular signals that involve neurotrophins and axon guidance cues to modulate the cytoskeletal response associated with neurite outgrowth at both the transcriptional and post-translational level. Here, we review our current knowledge of this topic and speculate about future research directions that involve p53 and related molecular pathways and that might advance our understanding of neurite outgrowth and axonal regeneration at the molecular level.
Authors:
Simone Di Giovanni; Khizr Rathore
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-22
Journal Detail:
Title:  Cell and tissue research     Volume:  -     ISSN:  1432-0878     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory for NeuroRegeneration and Repair, Hertie Institute for Clinical and Brain Research, University of Tübingen, Otfried-Mueller-Strasse 27, 72076, Tübingen, Germany, simone.digiovanni@medizin.uni-tuebingen.de.
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