| p53 codon 72 polymorphism in basal cell carcinoma of the skin. | |
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MedLine Citation:
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PMID: 16554913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basal cell carcinoma (BCC) is the most prevalent cancer in Iran. A common polymorphism at codon 72 of exon 4 of p53 tumor suppressor gene has been reported to be associated with increased inheritable susceptibility to several cancers. In the present study the frequency of p53 codon 72 polymorphism in 91 patients with BCC of skin, compared to 465 healthy normal individuals, was investigated. In total, there was no significant difference in the p53 genotypes between patients and controls. However, there was an apparent increase in the Arg/Arg genotype among those BCC patients who had a history of occupational sun exposure, compared to non-exposed patients (46.3% vs. 23.1%, P=0.11). A trend of increase in the frequency of Arg allele among sun-exposed patients was also observed (69.4% vs. 53.8%, P=0.07). Comparison of the genotype frequencies between sunexposed patients and normal controls confirmed the accumulation of Arg/Arg genotype in these patients (46.3% vs. 34.8%, P = 0.07). In addition, the frequency of Arg allele was significantly higher in sunexposed patients compared to controls (69.4% vs. 58.2%, P=0.03). Our results suggest that Arg allele at codon 72 of p53 gene might affect the risk of ultraviolet-induced basal cell carcinoma. |
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Authors:
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Abdulmohammad Pezeshki; Fatemeh Sari-Aslani; Abbas Ghaderi; Mehrnoosh Doroudchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-23 |
Journal Detail:
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Title: Pathology oncology research : POR Volume: 12 ISSN: 1219-4956 ISO Abbreviation: Pathol. Oncol. Res. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-03-23 Completed Date: 2006-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9706087 Medline TA: Pathol Oncol Res Country: England |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Shiraz Institute for Cancer Research, ICR, Shiraz University of Medical Sciences, Shiraz, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Codon Environmental Exposure Female Genes, p53 / genetics* Genetic Predisposition to Disease Humans Iran Male Middle Aged Neoplasms, Basal Cell / genetics* Occupational Exposure Polymorphism, Genetic* Skin Neoplasms / genetics* Solar System Ultraviolet Rays / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Codon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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