Document Detail


p53 codon 72 polymorphism in basal cell carcinoma of the skin.
MedLine Citation:
PMID:  16554913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Basal cell carcinoma (BCC) is the most prevalent cancer in Iran. A common polymorphism at codon 72 of exon 4 of p53 tumor suppressor gene has been reported to be associated with increased inheritable susceptibility to several cancers. In the present study the frequency of p53 codon 72 polymorphism in 91 patients with BCC of skin, compared to 465 healthy normal individuals, was investigated. In total, there was no significant difference in the p53 genotypes between patients and controls. However, there was an apparent increase in the Arg/Arg genotype among those BCC patients who had a history of occupational sun exposure, compared to non-exposed patients (46.3% vs. 23.1%, P=0.11). A trend of increase in the frequency of Arg allele among sun-exposed patients was also observed (69.4% vs. 53.8%, P=0.07). Comparison of the genotype frequencies between sunexposed patients and normal controls confirmed the accumulation of Arg/Arg genotype in these patients (46.3% vs. 34.8%, P = 0.07). In addition, the frequency of Arg allele was significantly higher in sunexposed patients compared to controls (69.4% vs. 58.2%, P=0.03). Our results suggest that Arg allele at codon 72 of p53 gene might affect the risk of ultraviolet-induced basal cell carcinoma.
Authors:
Abdulmohammad Pezeshki; Fatemeh Sari-Aslani; Abbas Ghaderi; Mehrnoosh Doroudchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-23
Journal Detail:
Title:  Pathology oncology research : POR     Volume:  12     ISSN:  1219-4956     ISO Abbreviation:  Pathol. Oncol. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-23     Completed Date:  2006-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706087     Medline TA:  Pathol Oncol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Affiliation:
Shiraz Institute for Cancer Research, ICR, Shiraz University of Medical Sciences, Shiraz, Iran.
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MeSH Terms
Descriptor/Qualifier:
Codon
Environmental Exposure
Female
Genes, p53 / genetics*
Genetic Predisposition to Disease
Humans
Iran
Male
Middle Aged
Neoplasms, Basal Cell / genetics*
Occupational Exposure
Polymorphism, Genetic*
Skin Neoplasms / genetics*
Solar System
Ultraviolet Rays / adverse effects
Chemical
Reg. No./Substance:
0/Codon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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