| p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. | |
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MedLine Citation:
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PMID: 17309603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The p53 protein can control cell cycle progression, programmed cell death, and differentiation of many cell types. Ectopic expression of p53 can resume capability of cell cycle arrest, differentiation, and apoptosis in various leukemic cell lines. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controlling apoptosis and differentiation/proliferation are independent. |
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Authors:
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Jarmila Navrátilová; Viktor Horváth; Alois Kozubík; Antonín Lojek; Joseph Lipsick; Jan Smarda |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-02-16 |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: 75 ISSN: 0301-4681 ISO Abbreviation: Differentiation Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-29 Completed Date: 2007-10-30 Revised Date: 2013-01-17 |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: England |
Other Details:
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Languages: eng Pagination: 592-604 Citation Subset: IM |
Affiliation:
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Institute of Experimental Biology, Faculty of Science, Masaryk University, Kotlárská 2, 611 37 Brno, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / genetics Cell Cycle / genetics Cell Differentiation / genetics, physiology* Cell Line, Transformed Cell Proliferation* Chickens G2 Phase / genetics Growth Inhibitors / genetics, physiology* Humans Monocytes / cytology* Oncogene Proteins v-myb / genetics* Signal Transduction / genetics Transfection Tumor Suppressor Protein p53 / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA128836/CA/NCI NIH HHS; R01 CA43592/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Oncogene Proteins v-myb; 0/Tumor Suppressor Protein p53 |
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