Document Detail


p53 accumulation in colorectal cancer with hepatic metastasis.
MedLine Citation:
PMID:  8641968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of immunoreactive p53 and argyrophilic nucleolar organizer region (AgNOR) numbers were compared between colorectal cancers with (n=44) and without (n=51) hepatic metastasis for at least 5 years. At the same time, the distribution of p53-positive cells in primary, metastatic, and xenografted tumors from the same individuals were studied. Overall, p53 positivity was found more frequently in the cases with hepatic metastasis than in non-metastatic controls, regardless of the distribution pattern (P<0.05), whereas AgNOR counts were not different between the two groups. Significant heterogeneity in the distribution of p53 immunoreactivity was noted in both the primary and metastatic lesions. The intratumor distribution patterns of p53 immunoreactive cells in the primary (n=33), metastatic (n=33), and xenografted (n=7) tumors of the same individuals were consistent in the majority of cases. There were a few cases in which the p53 immunoreactive cells were more dominant in the metastatic tumor cells. Our observations suggest that p53 accumulation in colorectal cancer is associated with increased risk for hepatic metastasis, while cell proliferation as represented by AgNOR numbers is not. In addition, heterogeneity of abnormal p53 accumulation in the tumor is maintained during the course of metastasis and even after implantation in nude mouse. p53-Immunoreactive cells in the population of colorectal cancer cells do not necessarily have higher metastasizing potential.
Authors:
K Maruyama; T Tanaka; S Baba; S Nakamura; Y Endo; H Sugimura
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of cancer research : Gann     Volume:  87     ISSN:  0910-5050     ISO Abbreviation:  Jpn. J. Cancer Res.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-07-17     Completed Date:  1996-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8509412     Medline TA:  Jpn J Cancer Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  368-76     Citation Subset:  IM    
Affiliation:
Second Department of Surgery, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Colorectal Neoplasms / metabolism*,  pathology*,  ultrastructure
Female
Humans
Immunohistochemistry
Liver Neoplasms / metabolism*,  secondary*,  ultrastructure
Male
Mice
Mice, Nude
Middle Aged
Molecular Sequence Data
Neoplasm Recurrence, Local
Nucleolus Organizer Region
Silver Staining
Transplantation, Heterologous
Tumor Suppressor Protein p53 / metabolism*
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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