| p53 Protein expression in squamous cell carcinomas from sun-exposed and non-sun-exposed sites. | |
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MedLine Citation:
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PMID: 8077465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In sun-exposed nonmelanoma skin cancers, observation of specific p53 gene mutations implicate the role of UV radiation-induced mutations in the pathogenesis of these tumors. Immunohistochemical p53 protein overexpression and p53 gene mutation have been frequently considered related events. OBJECTIVE: We investigated the differences in p53 immunostaining in squamous cell carcinomas (SCCs) with varying degrees of differentiation, from both chronically sun-exposed and sun-protected sites of the skin. METHODS: Twenty-six SCCs (15 UV-related and 11 UV-unrelated) and five specimens of Bowen's disease (in situ SCC) from sun-exposed skin were examined by means of BP53-12-1 monoclonal antibody immunohistochemistry. RESULTS: p53 Immunoreactivity was observed in 66.7% of sun-exposed, 54.5% of non-sun-exposed invasive SCCs (Fisher's exact test, p = 0.689), and 80% of Bowen's disease specimens. In 50% of all samples, p53 positivity was more prominent in the proliferating periphery of the tumor with gradual loss of positivity as the cells differentiated. CONCLUSION: The reliability of p53 immunohistochemistry needs further molecular genetic studies. |
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Authors:
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Y Oram; I Orengo; S C Baer; T Ocal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 31 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-09-30 Completed Date: 1994-09-30 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 417-22 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Baylor College of Medicine, Houston, TX. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bowen's Disease / metabolism Carcinoma, Squamous Cell / metabolism* Humans Immunohistochemistry Male Middle Aged Skin Neoplasms / metabolism* Sunlight* Tumor Suppressor Protein p53 / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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