| p53 and PCNA expression in carcinogenesis of the oropharyngeal mucosa. | |
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MedLine Citation:
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PMID: 7719225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperplastic lesions of the oral mucosa such as leukoplakia and oral lichen planus can eventually develop into squamous cell carcinomas (SCC) and provide an excellent model for multistage carcinogenesis. The development of carcinomas is assumed to be the result of interaction of genetic factors, locally applied carcinogens and immunological unresponsiveness. The purpose of this study was, therefore, to determine the role of alterations of the tumour suppressor gene p53, and the proliferation status of the lesions determined by PCNA expression. We investigated p53 and PCNA expression in 265 tissue sections of normal mucosa, premalignant, malignant and metastatic lesions of the oral mucosa by immunohistology. Quantitative analysis showed a gradual increase in PCNA expression from normal mucosa to moderately differentiated SCC. p53 expression was detectable in benign premalignant lesions. The increase in the number of p53-positive biopsies was correlated with the dysplasia and loss of differentiation in the premalignant and malignant lesions. |
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Authors:
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S C Girod; H D Pape; G R Krueger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of cancer. Part B, Oral oncology Volume: 30B ISSN: 0964-1955 ISO Abbreviation: Eur. J. Cancer, B, Oral Oncol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1995-05-24 Completed Date: 1995-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9214373 Medline TA: Eur J Cancer B Oral Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 419-23 Citation Subset: D; IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, University of Cologne, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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genetics,
metabolism Gene Expression Regulation, Neoplastic Genes, p53 Humans Leukoplakia / genetics Lichen Planus / genetics Mouth Mucosa / metabolism Mouth Neoplasms / genetics Oropharyngeal Neoplasms / genetics, metabolism* Proliferating Cell Nuclear Antigen / genetics, metabolism* Tumor Suppressor Protein p53 / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Proliferating Cell Nuclear Antigen; 0/Tumor Suppressor Protein p53 |
| Comments/Corrections | |
Comment In:
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Eur J Cancer B Oral Oncol. 1995 Nov;31B(6):403-4
[PMID:
8746274
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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