Document Detail

p53 and PCNA expression in carcinogenesis of the oropharyngeal mucosa.
MedLine Citation:
PMID:  7719225     Owner:  NLM     Status:  MEDLINE    
Hyperplastic lesions of the oral mucosa such as leukoplakia and oral lichen planus can eventually develop into squamous cell carcinomas (SCC) and provide an excellent model for multistage carcinogenesis. The development of carcinomas is assumed to be the result of interaction of genetic factors, locally applied carcinogens and immunological unresponsiveness. The purpose of this study was, therefore, to determine the role of alterations of the tumour suppressor gene p53, and the proliferation status of the lesions determined by PCNA expression. We investigated p53 and PCNA expression in 265 tissue sections of normal mucosa, premalignant, malignant and metastatic lesions of the oral mucosa by immunohistology. Quantitative analysis showed a gradual increase in PCNA expression from normal mucosa to moderately differentiated SCC. p53 expression was detectable in benign premalignant lesions. The increase in the number of p53-positive biopsies was correlated with the dysplasia and loss of differentiation in the premalignant and malignant lesions.
S C Girod; H D Pape; G R Krueger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer. Part B, Oral oncology     Volume:  30B     ISSN:  0964-1955     ISO Abbreviation:  Eur. J. Cancer, B, Oral Oncol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-05-24     Completed Date:  1995-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9214373     Medline TA:  Eur J Cancer B Oral Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, University of Cologne, Germany.
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MeSH Terms
Carcinoma, Squamous Cell / genetics,  metabolism
Gene Expression Regulation, Neoplastic
Genes, p53
Leukoplakia / genetics
Lichen Planus / genetics
Mouth Mucosa / metabolism
Mouth Neoplasms / genetics
Oropharyngeal Neoplasms / genetics,  metabolism*
Proliferating Cell Nuclear Antigen / genetics,  metabolism*
Tumor Suppressor Protein p53 / biosynthesis*
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 0/Tumor Suppressor Protein p53
Comment In:
Eur J Cancer B Oral Oncol. 1995 Nov;31B(6):403-4   [PMID:  8746274 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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