| The p53-MDM2 network: from oscillations to apoptosis. | |
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MedLine Citation:
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PMID: 17914240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress. In normal cells, the level of p53 proteins is kept low by MDM2, i.e. MDM2 negatively regulates the activity of p53. In the case of DNA damage, the p53-mediated pathways are activated leading to cell cycle arrest and repair of the DNA. If repair is not possible due to excessive damage, the p53-mediated apoptotic pathway is activated bringing about cell death. In this paper, we give an overview of our studies on the p53-MDM2 module and the associated pathways from a systems biology perspective. We discuss a number of key predictions, related to some specific aspects of cell cycle arrest and cell death, which could be tested in experiments. |
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Authors:
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Indrani Bose; Bhaswar Ghosh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of biosciences Volume: 32 ISSN: 0250-5991 ISO Abbreviation: J. Biosci. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-10-04 Completed Date: 2007-11-13 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8100809 Medline TA: J Biosci Country: India |
Other Details:
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Languages: eng Pagination: 991-7 Citation Subset: IM |
Affiliation:
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Department of Physics, Bose Institute,93/1, APC Road, Kolkata 700 009, India. indbose@yahoo.co.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Biological Clocks / physiology Humans Proto-Oncogene Proteins c-mdm2 / physiology* Signal Transduction / physiology Systems Biology* Tumor Suppressor Protein p53 / antagonists & inhibitors*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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