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p53 Codon 72 Polymorphism and Coronary Artery Disease: Evidence of Association With Left Ventricular Ejection Fraction.
MedLine Citation:
PMID:  21844794     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION:: Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD). METHODS:: The authors have studied 198 subjects admitted consecutively to Valmontone Hospital for CAD and 129 subjects admitted for cardiovascular diseases without CAD. Fifty-nine subjects admitted for CAD to Division of Cardiac Surgery of Tor Vergata University were also studied. All subjects were from the white population. The p53 polymorphism was evaluated using the restriction fragment length polymorphism polymerase chain reaction. RESULTS:: p53 codon 72 polymorphism is a significant independent predictor of LVEF in subjects with CAD but not in subjects with cardiovascular disease without CAD. In subjects with CAD, LVEF is significantly lower in subjects carrying the *Pro variant than in *Arg/*Arg subjects. This effect is more evident in subjects with a positive history of infarction. CONCLUSIONS:: Our study points to a significant relationship of p53 codon 72 polymorphism with cardiac function in subjects with CAD.
Authors:
Fulvia Gloria-Bottini; Maria Banci; Patrizia Saccucci; Paolo Nardi; Mattia Scognamiglio; Federica Papetti; Andrea Magrini; Antonio Pellegrino; Egidio Bottini; Luigi Chiariello
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-12
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Biopathology and Imaging Diagnostics (fg-b, ps, am, eb), University of Rome Tor Vergata, School of Medicine; Department of Cardiology (mb, fp), Valmontone Hospital; and Department of Cardiac Surgery (pn, ms, ap, lc), University of Rome Tor Vergata, School of Medicine, Rome, Italy.
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