Document Detail


The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.
MedLine Citation:
PMID:  23049825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field.
METHODS: Genotypes for the p53 codon 72 polymorphism (Pro/Arg) were obtained for 264 POAG patients and 400 controls from the U.S. and in replication studies for 308 POAG patients and 178 controls from Australia (GIST). The glaucoma patients were divided into two groups according to location of initial visual field defect (either paracentral or peripheral). All cases and controls were Caucasian with European ancestry.
RESULTS: The p53-PRO/PRO genotype was more frequent in the U.S. POAG patients with early visual field defects in the paracentral regions compared with those in the peripheral regions or control group (p=2.7 × 10(-5)). We replicated this finding in the GIST cohort (p  =7.3 × 10(-3), and in the pooled sample (p=6.6 × 10(-7)) and in a meta-analysis of both the US and GIST datasets (1.3 × 10(-6), OR 2.17 (1.58-2.98 for the PRO allele).
CONCLUSIONS: These results suggest that the p53 codon 72 PRO/PRO genotype is potentially associated with early paracentral visual field defects in primary open-angle glaucoma patients.
Authors:
Janey L Wiggs; Alex W Hewitt; Bao Jian Fan; Dan Yi Wang; Dayse R Figueiredo Sena; Colm O'Brien; Anthony Realini; Jamie E Craig; David P Dimasi; David A Mackey; Jonathan L Haines; Louis R Pasquale
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-26
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-05-07     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45613     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Apoptosis
Case-Control Studies
Codon
Cohort Studies
European Continental Ancestry Group / genetics
Female
Genotype
Glaucoma, Open-Angle / genetics*
Humans
Male
Middle Aged
Proline / genetics*
Scotoma / genetics
Tumor Suppressor Protein p53 / metabolism*
Visual Fields
Grant Support
ID/Acronym/Agency:
P30EY014104/EY/NEI NIH HHS; R01EY015473/EY/NEI NIH HHS; R01EY015872/EY/NEI NIH HHS; R21 EY022766/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Codon; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 9DLQ4CIU6V/Proline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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