Document Detail

p300 expression is related to high-risk human papillomavirus infections and severity of cervical intraepithelial neoplasia but not to viral or disease outcomes in a longitudinal setting.
MedLine Citation:
PMID:  20173499     Owner:  NLM     Status:  MEDLINE    
To evaluate the role of the expression of the transcription factor p300 as an independent predictor of high-risk human papillomavirus (HR-HPV) infections and outcome of the cervical disease.Cervical biopsy samples taken at enrolment from 225 women of the Latin American Screening study cohort were analyzed for p300 using immunohistochemistry to assess its value as predictor of (a) cervical intraepithelial neoplasia (CIN) grade, and (b) HR-HPV at baseline, as well as (c) outcomes of HR-HPV infections, and (d) development of incident CIN as surrogate endpoints of progressive disease.There was a significant linear trend in increasing upregulation (=pattern shift) of p300 (P=0.0001) in parallel with increasing grade of CIN. When dichotomized (normal/moderately increase vs. strong-intense), upregulated p300 expression predicted CIN3+ with odds ratio=4.16 (95% confidence interval: 1.95-8.86) (P=0.0001) and CIN2+ with odds ratio=3.48 (95% confidence interval: 1.86-6.48) (P=0.0001). p300 was upregulated more often in HR-HPV+ lesions than in those remaining negative. Semiquantitative viral loads were also directly related to upregulation of p300 (P=0.036), but p300 was not a significant predictor of disease progression to either CIN1+ or CIN2+.p300 expression was upregulated in CIN lesions and related to detection and viral load of HR-HPV but not to their outcome or to incident CIN.
Stina Syrj?nen; Paulo Naud; Luis Sarian; Sophie Derchain; Cecilia Roteli-Martins; Adhemar Longatto-Filho; Silvio Tatti; Margherita Branca; Mojca Erzen; Luciano Serpa-Hammes; Jean Matos; Fernanda Arlindo; Marina Sakamoto-Maeda; Silvano Costa; Kari Syrj?nen
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  29     ISSN:  1538-7151     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-45     Citation Subset:  IM    
Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland.
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MeSH Terms
Cervical Intraepithelial Neoplasia / genetics,  metabolism*,  virology*
Cohort Studies
DNA, Viral / genetics
E1A-Associated p300 Protein / biosynthesis*,  genetics
Longitudinal Studies
Papillomaviridae / genetics,  physiology*
Papillomavirus Infections / genetics,  metabolism*,  pathology,  virology*
Prospective Studies
Statistics, Nonparametric
Tumor Markers, Biological / biosynthesis*,  genetics
Reg. No./Substance:
0/DNA, Viral; 0/Tumor Markers, Biological; EC p300 Protein; EC protein, human

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