Document Detail


p202 self-associates through a sequence conserved among the members of the 200-family proteins.
MedLine Citation:
PMID:  9821952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Murine p202 is an interferon-inducible primarily nuclear phosphoprotein (52 kDa) whose expression in transfected cells inhibits colony formation. p202-binding proteins include the pocket proteins (pRb, p107 and p130), a p53-binding protein (sm53BP1), and transcription factors (e.g. NF-kappaB (p50 and p65), AP-1 (c-Fos and c-Jun), E2F-1, E2F-4, MyoD, and myogenin). p202 modulates the transcriptional activity of these factors in transfected cells. Here we demonstrate that p202 self-associates directly and a sequence in p202, which is conserved among the members of the 200-family proteins, was sufficient for self-association in vitro. Our observations reported herein raise the possibility that self-association of p202 may provide a mechanism for the regulation of its activity.
Authors:
D Koul; N U Obeyesekere; J U Gutterman; G B Mills; D Choubey
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  438     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-02     Completed Date:  1998-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Department of Molecular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Binding Sites
Binding, Competitive
Carrier Proteins / chemistry,  metabolism*
Chromatography, Affinity
Conserved Sequence*
Cross-Linking Reagents
Dimerization
Dimethyl Suberimidate
Glutathione Transferase / metabolism
Intracellular Signaling Peptides and Proteins*
Mice
Multigene Family
Nuclear Proteins / metabolism
Peptides / metabolism
Phosphoproteins / chemistry,  metabolism*
Protein Binding
Protein Biosynthesis
Recombinant Fusion Proteins / metabolism
Sequence Deletion
Grant Support
ID/Acronym/Agency:
CA69031/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Cross-Linking Reagents; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/Peptides; 0/Phosphoproteins; 0/Recombinant Fusion Proteins; 0/Trp53bp1 protein, mouse; 29878-26-0/Dimethyl Suberimidate; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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