Document Detail


p120(cat) Delocalization in cell lines of oral cancer.
MedLine Citation:
PMID:  11755823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: As already reported for E-cadherin, beta- and gamma-catenin, p120 expression showed a homogeneous membranous localization in normal oral specimens. The intensity of staining for p120 progressively increased from basal and parabasal layers toward the intermediate spinous layer. No staining for p120 was observed in the upper layer. NCTC showed a membranous positivity. OSC 20, CAL 33 and CAL 27 showed a membranous positivity, even if polarized to cell-cell adhesion sites, in 40-50% of cells. OSC 20, CAL 33 and CAL 27 cells showed also a cytoplasmic delocalization. All positive KB cells showed a prevalent cytoplasmic staining and 10% of these cells showed a nuclear delocalization. In cancer cells, p120 showed an inverse relationship with the degree of differentiation for a progressive displacement of the signal toward the cytoplasm or nucleus in dedifferentiated cells. In conclusions, this nuclear delocalization for p120 could suppose its potential involvement in signalling and cancer transformation.
Authors:
L Lo Muzio; G Pannone; S Staibano; M D Mignogna; R Serpico; S Fanali; G De Rosa; A Piattelli; M A Mariggiò
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral oncology     Volume:  38     ISSN:  1368-8375     ISO Abbreviation:  Oral Oncol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-02-07     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-72     Citation Subset:  IM    
Affiliation:
Institute of Dental Sciences, University of Ancona, Ancona, Italy. llomuzio@tin.it
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / metabolism*
Case-Control Studies
Catenins
Cell Adhesion Molecules / metabolism*
Cell Differentiation / physiology
Cell Membrane / metabolism
Cytoplasm / metabolism
Humans
Immunohistochemistry / methods
Mouth Neoplasms / metabolism*
Neoplasm Proteins / metabolism*
Phosphoproteins / metabolism*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Catenins; 0/Cell Adhesion Molecules; 0/Neoplasm Proteins; 0/Phosphoproteins; 0/delta catenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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