| p120-catenin mediates inflammatory responses in the skin. | |
MedLine Citation:
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PMID: 16469707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic studies in lower eukaryotes have not revealed a role for this protein in vivo. Using conditional targeting in mice, we show that p120 null neonatal epidermis exhibits reduced intercellular AJ components but no overt disruption in barrier function or intercellular adhesion. As the mice age, however, they display epidermal hyperplasia and chronic inflammation, typified by hair degeneration and loss of body fat. Using skin engraftments and anti-inflammatory drugs, we show that these features are not attributable to reductions in junctional cadherins and catenins, but rather NFkB activation. Both in vivo and in vitro, p120 null epidermal cells activate nuclear NFkB, triggering a cascade of proinflammatory NFkB targets. Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function. |
Authors:
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Mirna Perez-Moreno; Michael A Davis; Ellen Wong; H Amalia Pasolli; Albert B Reynolds; Elaine Fuchs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Cell Volume: 124 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-10 Completed Date: 2006-03-20 Revised Date: 2014-09-11 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 631-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adherens Junctions
/
metabolism,
pathology Animals Animals, Newborn Catenins Cell Adhesion Molecules / deficiency, genetics, metabolism* Dermatitis / etiology, metabolism, pathology Humans Hyperplasia Inflammation / etiology*, metabolism, pathology Mice Mice, Knockout Mice, Transgenic NF-kappa B / metabolism Phosphoproteins / deficiency, genetics, metabolism* Skin / metabolism*, pathology rho GTP-Binding Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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CA55724/CA/NCI NIH HHS; P50 CA95103/CA/NCI NIH HHS; R01 AR027883/AR/NIAMS NIH HHS; R01 AR027883-29/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catenins; 0/Cell Adhesion Molecules; 0/NF-kappa B; 0/Phosphoproteins; 0/delta catenin; EC 3.6.5.2/rho GTP-Binding Proteins |
| Comments/Corrections | |
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