Document Detail


p120-catenin mediates inflammatory responses in the skin.
MedLine Citation:
PMID:  16469707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic studies in lower eukaryotes have not revealed a role for this protein in vivo. Using conditional targeting in mice, we show that p120 null neonatal epidermis exhibits reduced intercellular AJ components but no overt disruption in barrier function or intercellular adhesion. As the mice age, however, they display epidermal hyperplasia and chronic inflammation, typified by hair degeneration and loss of body fat. Using skin engraftments and anti-inflammatory drugs, we show that these features are not attributable to reductions in junctional cadherins and catenins, but rather NFkB activation. Both in vivo and in vitro, p120 null epidermal cells activate nuclear NFkB, triggering a cascade of proinflammatory NFkB targets. Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function.
Authors:
Mirna Perez-Moreno; Michael A Davis; Ellen Wong; H Amalia Pasolli; Albert B Reynolds; Elaine Fuchs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cell     Volume:  124     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-20     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  631-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adherens Junctions / metabolism,  pathology
Animals
Animals, Newborn
Catenins
Cell Adhesion Molecules / deficiency,  genetics,  metabolism*
Dermatitis / etiology,  metabolism,  pathology
Humans
Hyperplasia
Inflammation / etiology*,  metabolism,  pathology
Mice
Mice, Knockout
Mice, Transgenic
NF-kappa B / metabolism
Phosphoproteins / deficiency,  genetics,  metabolism*
Skin / metabolism*,  pathology
rho GTP-Binding Proteins / metabolism
Grant Support
ID/Acronym/Agency:
CA55724/CA/NCI NIH HHS; P50 CA95103/CA/NCI NIH HHS; R01 AR027883/AR/NIAMS NIH HHS; R01 AR027883-29/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Catenins; 0/Cell Adhesion Molecules; 0/NF-kappa B; 0/Phosphoproteins; 0/delta catenin; EC 3.6.5.2/rho GTP-Binding Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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