Document Detail

The oxygen cost of breathing in patients with cardiorespiratory disease.
MedLine Citation:
PMID:  7091914     Owner:  NLM     Status:  MEDLINE    
We measured the oxygen cost of breathing (VO2resp) in 13 patients with cardiorespiratory disease requiring artificial ventilation as the difference between the oxygen consumption during spontaneous respiration (VO2tot) and that during artificial ventilation (VO2nonresp). Average VO2tot was 312 +/- 90 ml/min (mean +/- 1 SD), whereas VO2nonresp was 246 +/- 38 ml/min (p less than 0.01). Average VO2resp was 75 +/- 82 ml/min (range, 8 to 286), representing 24% of VO2tot or 8.7 +/- 8.9 ml O2/L ventilation. In normal resting adults, VO2resp in 5 to 10 ml/min, about 1 to 3% VO2tot, or 0.25 to 2.5 ml O2/L ventilation. The VO2resp had an exponential relationship with FEV1 (r = 0.97) in 6 patients who had had prior spirometry. Because minute ventilation was normal in our patients (8.8 +/- 2.2 L/min), the elevated VO2resp represented an increase in the work of breathing as well as a decrease in the efficiency of the respiratory muscles. These results suggest that, where O2 transport is compromised, artificial ventilation may release substantial quantities of oxygen for use by other body systems.
S Field; S M Kelly; P T Macklem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  126     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  AIM; IM    
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MeSH Terms
Forced Expiratory Volume
Heart Diseases / physiopathology*
Middle Aged
Oxygen Consumption*
Respiration Disorders / physiopathology*
Respiration, Artificial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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