Document Detail


The oxygen affinity of sickle hemoglobin.
MedLine Citation:
PMID:  18249588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (S(o)(2)), even when oxygen partial pressure (P(o)(2)) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivo S(o)(2) is normal when P(o)(2) is normal. We retrospectively examined 50 blood gas and COoximetry samples from SCD patients and from controls matched for pH, P(o)(2), and carboxyhemoglobin. Control data fell close to the Severinghaus curve, as did non-hypoxemic ( [Formula: see text] ) SCD data. In contrast, hypoxemic (S(o)(2)) < 92.5% SCD data fell well below the standard curve. Thus, although SCD patients' oxygen affinity is low under hypoxic conditions, it is normal at normal arterial S(o)(2). Therefore, a finding of abnormally low saturation demonstrates that P(o)(2) is abnormally low. Given our previous finding that pulse oximetry faithfully reflects saturation in SCD, low pulse oximeter readings in SCD constitute reliable evidence of impaired gas exchange.
Authors:
Amgad Abdu; José Gómez-Márquez; Thomas K Aldrich
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Publication Detail:
Type:  Journal Article     Date:  2007-12-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  161     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-24     Revised Date:  2008-07-14    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  92-4     Citation Subset:  IM    
Affiliation:
Pulmonary Medicine Division, Albert Einstein College of Medicine, Bronx, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia, Sickle Cell / blood*,  physiopathology*
Anoxia / blood
Blood Gas Analysis
Carboxyhemoglobin / analysis
Female
Hemoglobin, Sickle / physiology*
Humans
Male
Middle Aged
Oximetry
Oxygen / blood*
Oxyhemoglobins / analysis
Chemical
Reg. No./Substance:
0/Hemoglobin, Sickle; 0/Oxyhemoglobins; 7782-44-7/Oxygen; 9061-29-4/Carboxyhemoglobin

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