| The oxidative disposition of potassium cyanide in mice. | |
| | |
MedLine Citation:
|
PMID: 3000027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The role of oxidative metabolism in the disposition of potassium cyanide (KCN), was investigated in mice administered KCN, (4.6 mg/kg, s.c.) containing 4.5 microCi [14C]KCN. The expired pulmonary metabolites, [14C]hydrocyanic acid (HCN) and 14CO2, were collected and analyzed. Approximately 1% and 2% of the KCN dose was expired as [14C]HCN and 14CO2, respectively. Expiration of the pulmonary metabolites was decreased following pretreatment with sodium nitrite, sodium thiosulfate, oxygen, or a combination of cyanide antidotes. Treatment with hydrogen peroxide lowered the amount of [14C]HCN expired and did not alter the expiration of 14CO2. Treatment with 3-amino-1,2,4-triazole (catalase inhibitor), superoxide dismutase, or diethyldithiocarbamic acid (superoxide dismutase inhibitor) did not change the amount of [14C]HCN expired. However, superoxide dismutase significantly increased the amount of 14CO2 expired, whereas diethyldithiocarbamic acid decreased 14CO2 expiration. The results from these studies suggest that in vivo cyanide can be oxidized to CO2 and treatment with agents that alter the availability of endogenous superoxide and/or hydrogen peroxide can alter the rate of cyanide oxidation. |
| | |
Authors:
|
J D Johnson; G E Isom |
Related Documents
:
|
9733537 - The biosynthesis of erucic acid in developing embryos of brassica rapa 3619637 - In vitro aging of red blood cells and lipid peroxidation. 18969597 - Determination of lead in vinegar by icp-ms and gfaas: evaluation of different sample pr... 14598907 - Gallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocyt... 19127547 - Liquid chromatography coupled with ultraviolet absorbance detection, electrospray ioniz... 3382687 - Isolation and characterization of a novel four-chain ether lipid from clostridium butyr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Toxicology Volume: 37 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1985 Dec |
Date Detail:
|
Created Date: 1986-01-10 Completed Date: 1986-01-10 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 215-24 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amitrole
/
pharmacology Animals Breath Tests Carbon Dioxide / analysis Carbon Radioisotopes Cyanides / metabolism* Drug Interactions Hydrogen Cyanide / analysis Hydrogen Peroxide / pharmacology Injections, Subcutaneous Kinetics Lung / drug effects, metabolism* Male Metabolic Detoxication, Drug Mice Oxidation-Reduction Oxygen / pharmacology Potassium Cyanide / metabolism* Superoxide Dismutase / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Cyanides; 124-38-9/Carbon Dioxide; 151-50-8/Potassium Cyanide; 61-82-5/Amitrole; 74-90-8/Hydrogen Cyanide; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical significance of respiratory infection caused by Branhamella catarrhalis with special refere...
Next Document: Inhibition of mitochondrial respiration by asteltoxin, a respiratory toxin from Emericella variecolo...