Document Detail

The oxidative disposition of potassium cyanide in mice.
MedLine Citation:
PMID:  3000027     Owner:  NLM     Status:  MEDLINE    
The role of oxidative metabolism in the disposition of potassium cyanide (KCN), was investigated in mice administered KCN, (4.6 mg/kg, s.c.) containing 4.5 microCi [14C]KCN. The expired pulmonary metabolites, [14C]hydrocyanic acid (HCN) and 14CO2, were collected and analyzed. Approximately 1% and 2% of the KCN dose was expired as [14C]HCN and 14CO2, respectively. Expiration of the pulmonary metabolites was decreased following pretreatment with sodium nitrite, sodium thiosulfate, oxygen, or a combination of cyanide antidotes. Treatment with hydrogen peroxide lowered the amount of [14C]HCN expired and did not alter the expiration of 14CO2. Treatment with 3-amino-1,2,4-triazole (catalase inhibitor), superoxide dismutase, or diethyldithiocarbamic acid (superoxide dismutase inhibitor) did not change the amount of [14C]HCN expired. However, superoxide dismutase significantly increased the amount of 14CO2 expired, whereas diethyldithiocarbamic acid decreased 14CO2 expiration. The results from these studies suggest that in vivo cyanide can be oxidized to CO2 and treatment with agents that alter the availability of endogenous superoxide and/or hydrogen peroxide can alter the rate of cyanide oxidation.
J D Johnson; G E Isom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  37     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-10     Completed Date:  1986-01-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  215-24     Citation Subset:  IM    
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MeSH Terms
Amitrole / pharmacology
Breath Tests
Carbon Dioxide / analysis
Carbon Radioisotopes
Cyanides / metabolism*
Drug Interactions
Hydrogen Cyanide / analysis
Hydrogen Peroxide / pharmacology
Injections, Subcutaneous
Lung / drug effects,  metabolism*
Metabolic Detoxication, Drug
Oxygen / pharmacology
Potassium Cyanide / metabolism*
Superoxide Dismutase / pharmacology
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Cyanides; 124-38-9/Carbon Dioxide; 151-50-8/Potassium Cyanide; 61-82-5/Amitrole; 74-90-8/Hydrogen Cyanide; 7722-84-1/Hydrogen Peroxide; 7782-44-7/Oxygen; EC Dismutase

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