| The oxazolomycins: a structurally novel class of bioactive compounds. | |
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MedLine Citation:
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PMID: 16472256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action. |
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Authors:
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Mark G Moloney; Paul C Trippier; Muhammad Yaqoob; Zhaoyang Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current drug discovery technologies Volume: 1 ISSN: 1570-1638 ISO Abbreviation: Curr Drug Discov Technol Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2006-02-13 Completed Date: 2006-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101157212 Medline TA: Curr Drug Discov Technol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 181-99 Citation Subset: IM |
Affiliation:
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The Department of Chemistry, The University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford. OX1 3TA, UK. mark.moloney@chemistry.oxford.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry*,
isolation & purification,
pharmacology Antibiotics, Antineoplastic / chemistry*, isolation & purification, pharmacology Antiviral Agents / chemistry*, isolation & purification, pharmacology Magnetic Resonance Spectroscopy Models, Molecular Oxazoles / chemistry*, isolation & purification, pharmacology Spiro Compounds / chemistry*, isolation & purification, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Antiviral Agents; 0/Oxazoles; 0/Spiro Compounds; 136360-48-0/diffusomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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