Document Detail


An ovine model of postinfarction dilated cardiomyopathy.
MedLine Citation:
PMID:  12238835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Coronary arterial disease is the major cause of congestive heart failure, but suitable animal models of postinfarction, dilated cardiomyopathy do not exist. This article describes an ovine model that develops after an anterobasal infarction.
METHODS: The distribution of ovine myocardium supplied by the first two diagonal branches of the left homonymous artery were determined in 20 slaughterhouse hearts and eight live sheep using methylene blue and tetrazolium injections, respectively. Seven additional animals had the infarction and underwent serial hemodynamic, microsphere and echocardiographic studies more than 8 weeks and histologic studies at the eighth week. Infarcts represented 24.6% +/- 4.7% and 23.9% +/- 2.2% of the left ventricular mass in slaughterhouse and live hearts, respectively.
RESULTS: During remodeling, left ventricular end-systolic and end-diastolic volumes increased 115% and 73%, respectively, ejection fraction decreased from 41.2% +/- 6.7% to 29.1% +/- 5.7%, systolic wall thickening remote from the infarct decreased by 68%, sphericity index increased from 0.465 +/- 0.088 to 0.524 +/- 0.038, and left ventricular end-diastolic pressure increased from 1.7 +/- 1.0 to 8.2 +/- 3.5 mm Hg. Serial microsphere measurements documented normal blood flow (1.34 mL/g per minute) to all uninfarcted myocardium and 22% of normal to the infarct. Viable myocardium showed mild interstitial fibrosis.
CONCLUSIONS: This ovine model meets all criteria for postinfarction, dilated cardiomyopathy and has the advantages of controlling for variations in coronary arterial anatomy, collateral vascularity, and differences in the numbers, location, and severity of atherosclerotic lesions that confound human studies of the pathogenesis of this disease. This simple model contains only infarcted and fully perfused, hypocontractile myocardium produced by a moderate-sized, regional infarction.
Authors:
Sina L Moainie; Joseph H Gorman; T Sloane Guy; Frank W Bowen; Benjamin M Jackson; Theodore Plappert; Navneet Narula; Martin G St John-Sutton; Jagat Narula; L Henry Edmunds; Robert C Gorman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  74     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-19     Completed Date:  2002-10-01     Revised Date:  2013-09-09    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  753-60     Citation Subset:  AIM; IM    
Affiliation:
Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Volume / physiology
Cardiomyopathy, Dilated / pathology,  physiopathology*
Coronary Circulation / physiology
Disease Models, Animal*
Echocardiography
Hemodynamics / physiology*
Myocardial Contraction / physiology
Myocardial Infarction / pathology,  physiopathology*
Myocardium / pathology
Sheep
Stroke Volume / physiology
Ventricular Remodeling / physiology*
Grant Support
ID/Acronym/Agency:
HL36308/HL/NHLBI NIH HHS; HL63594/HL/NHLBI NIH HHS; R01 HL063954/HL/NHLBI NIH HHS; R01 HL071137/HL/NHLBI NIH HHS

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