Document Detail

An ovine model of chronic stable heart failure.
MedLine Citation:
PMID:  10908088     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic stable large animal models of heart failure are difficult to establish. We report an ovine model of chronic stable heart failure achieved by a technique of repetitive myocardial infarctions (one of the most common causes of cardiac failure) with catheter-based techniques. METHODS AND RESULTS: Ejection fraction (EF) was assessed by echocardiography. A perfusion catheter was positioned in either the left anterior descending or circumflex artery by using standard angioplasty techniques. Myocardial infarction was induced by a Gelfoam embolism via this catheter and was confirmed by electrocardiographic (ECG) changes and new segmental abnormalities. The procedure was repeated at 2 weekly intervals until the EF was less than 40%. Target EF was achieved in 15 animals, with a mean of 3.4 embolizations (range 2 to 8). Baseline EF was 68%, with a mean final EF of 33%. This resulted in a 54% reduction in EF (range 44% to 68%) from baseline values. Two animals developed late symptomatic heart failure and died, whereas EF was stable at 3-month follow-up echocardiography in the remaining animals with no significant spontaneous improvement. CONCLUSION: Chronic stable heart failure can be established in sheep with catheter-based skills and a microembolization technique that causes repetitive myocardial infarctions.
G Devlin; K Matthews; G McCracken; S Stuart; J Jensen; J Conaglen; J Bass
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  6     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-02     Completed Date:  2000-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  IM    
Waikato Academic Division, University of Auckland, New Zealand.
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MeSH Terms
Catheterization, Peripheral / adverse effects
Chronic Disease
Disease Models, Animal*
Embolism / complications
Heart Failure / etiology*,  physiopathology,  ultrasonography
Myocardial Contraction
Myocardial Infarction / complications*,  etiology
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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