Document Detail


An overview of risk factors for poor neurodevelopmental outcome associated with prematurity.
MedLine Citation:
PMID:  23151855     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Preterm birth is a major cause of neonatal mortality and morbidity. While advances in medical care have improved the survival of preterm infants, neurodevelopmental problems persist in this population. This article aims to review factors associated with their neurodevelopmental outcomes.
DATA SOURCES: English language studies of neurodevelopmental outcomes in preterm infants were retrieved from PubMed. A total of 100 related publications were included.
RESULTS: Early gestational age and birth weight are the most significant predictors of poor long-term neurological outcome. Structural changes of the brain, infection, male gender and neonatal intensive care unit course are also important factors affecting eventual outcome. Other complex biological and socio-economic factors, which extend from prenatal through postnatal periods, up through and including adulthood, also affect the trajectory of brain development in preterm infants.
CONCLUSIONS: Neurodevelopmental problems continue to affect the preterm population. There is a critical need for collaboration among geneticists, obstetricians, pediatricians, and neuroimaging and rehabilitation experts to determine early predictive factors and neuroprotective therapies to properly treat or prevent poor neurodevelopmental outcomes in these infants.
Authors:
Tao Xiong; Fernando Gonzalez; De-Zhi Mu
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Publication Detail:
Type:  Journal Article     Date:  2012-11-15
Journal Detail:
Title:  World journal of pediatrics : WJP     Volume:  8     ISSN:  1867-0687     ISO Abbreviation:  World J Pediatr     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278599     Medline TA:  World J Pediatr     Country:  China    
Other Details:
Languages:  eng     Pagination:  293-300     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China.
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