Document Detail


An overview of recent advances in pathogenesis and diagnosis of preeclampsia.
MedLine Citation:
PMID:  22976257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia is a serious complication of pregnancy, which is the cause of 60 000 maternal deaths annually worldwide. In addition to the well-known maternal risk factors such as hypertension, diabetes mellitus, antiphospholipid antibody syndrome, obesity, aging, and multiple pregnancies, recent studies have identified the role of genetic and immunological factors in the pathogenesis of preeclampsia. In particular, imbalance between angiogenic and anti-angiogenic factors, anti-angiotensin II type 1 receptor antibodies and dysregulation of oxygen supplies can cause preeclampsia. A group of biomarkers have been introduced for diagnosis of preeclampsia. Chief among them is the ratio of soluble fms-like tyrosine kinase-1 to placental growth factor, which can be used in clinical practice. Recent studies have shown high specificity and sensitivity of these markers for early diagnosis of preeclampsia, which is critical for prevention of fetal and maternal complications.
Authors:
Shokoufeh Savaj; Nosratollah Vaziri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Iranian journal of kidney diseases     Volume:  6     ISSN:  1735-8604     ISO Abbreviation:  Iran J Kidney Dis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-03-01     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101316967     Medline TA:  Iran J Kidney Dis     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  334-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiogenic Proteins / blood
Antibodies / blood
Biological Markers / blood
Female
Humans
Incidence
Oxygen / blood
Pre-Eclampsia / blood,  diagnosis*,  etiology,  mortality,  physiopathology,  prevention & control
Predictive Value of Tests
Pregnancy
Prognosis
Risk Factors
Chemical
Reg. No./Substance:
0/Angiogenic Proteins; 0/Antibodies; 0/Biological Markers; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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