| An overview of the patient with ataxia. | |
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MedLine Citation:
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PMID: 15895274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ataxia, a neurological sign characterized by the incoordination of voluntary movements, is the most prominent manifestation of cerebellar disease. The cardinal features of cerebellar dysfunction involve disturbances of stance, gait, eye movements, muscle tone, skilled movements, and speech. Classification and differential diagnosis of ataxic syndromes have intrinsic complexity owing to the variability in phenotypic presentations and in etiologies, which include trauma, toxic and metabolic causes, neoplasms, immune mechanisms, and genetic diseases. Pure cerebellar symptoms are rarely observed, while the clinical picture of both genetic and sporadic ataxia syndromes is sometimes complicated by the presence of extracerebellar neurological or multisystem extraneural pathology. Clinical presentation and assessment of the patients together with classification, genetic aspects, and principles in differential diagnosis of ataxias are briefly reviewed. |
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Authors:
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Caterina Mariotti; Roberto Fancellu; Stefano Di Donato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of neurology Volume: 252 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-16 Completed Date: 2006-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 511-8 Citation Subset: IM |
Affiliation:
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Istituto Nazionale Neurologico, C. Besta IRCCS, via Celoria, 11, 20133 Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ataxia
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classification*,
diagnosis*,
genetics Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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