Document Detail


An overview of mortality and sequelae of preterm birth from infancy to adulthood.
MedLine Citation:
PMID:  18207020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Survival rates have greatly improved in recent years for infants of borderline viability; however, these infants remain at risk of developing a wide array of complications, not only in the neonatal unit, but also in the long term. Morbidity is inversely related to gestational age; however, there is no gestational age, including term, that is wholly exempt. Neurodevelopmental disabilities and recurrent health problems take a toll in early childhood. Subsequently hidden disabilities such as school difficulties and behavioural problems become apparent and persist into adolescence. Reassuringly, however, most children born very preterm adjust remarkably well during their transition into adulthood. Because mortality rates have fallen, the focus for perinatal interventions is to develop strategies to reduce long-term morbidity, especially the prevention of brain injury and abnormal brain development. In addition, follow-up to middle age and beyond is warranted to identify the risks, especially for cardiovascular and metabolic disorders that are likely to be experienced by preterm survivors.
Authors:
Saroj Saigal; Lex W Doyle
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Lancet     Volume:  371     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-01-31     Revised Date:  2008-03-27    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Paediatrics, McMaster University, Hamilton, ON, Canada. saigal@mcmaster.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Developed Countries
Female
Follow-Up Studies
Gestational Age*
Humans
Infant
Infant Mortality / trends*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  mortality*,  physiopathology
Intensive Care Units, Neonatal / economics
Male
Survival Rate
Comments/Corrections
Comment In:
Lancet. 2008 Mar 15;371(9616):897-8   [PMID:  18342681 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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