Document Detail

An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.
MedLine Citation:
PMID:  19534089     Owner:  NLM     Status:  MEDLINE    
Familial Mediterranean fever (FMF) is the earliest known autoinflammatory disease, characterized by symptoms such as arthritis, peritonitis, pleuritis, erysipelas-like erythema, and most importantly amyloidosis. This disease is very common in populations of the Mediterranean area, and due to its high carrier frequency and occurrence rate in these populations, it has been the focus of much research work. Such research has allowed greater insights into the genetics of FMF, leading to the discovery of the responsible gene in 1997 and the determination of mutations and their effect on the phenotype of patients, as well as the interactions and roles of the pyrin protein, which seems to have various roles in regulation of innate immunity, inflammation, and apoptosis. Colchicine has been used as preventive treatment since 1972, and recent studies have allowed the determination of its mode of action.
Hashem A Dbouk; Imad W Uthman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Le Journal médical libanais. The Lebanese medical journal     Volume:  56     ISSN:  0023-9852     ISO Abbreviation:  J Med Liban     Publication Date:    2008 Jan-Mar
Date Detail:
Created Date:  2009-06-18     Completed Date:  2009-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375352     Medline TA:  J Med Liban     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.
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MeSH Terms
Child, Preschool
Colchicine / therapeutic use*
Cytoskeletal Proteins / genetics*
DNA Mutational Analysis
Exons / genetics
Familial Mediterranean Fever / diagnosis,  drug therapy*,  genetics*
Genetics, Population
Tubulin Modulators / therapeutic use*
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Tubulin Modulators; 0/marenostrin; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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