| An overview on the development of a bio-artificial pancreas as a treatment of insulin-dependent diabetes mellitus. | |
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MedLine Citation:
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PMID: 16342061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper presents the concept and most of the research undertaken all over the world for the development of a bio-artificial pancreas (BAP) device over the last 30 years. The devices studied, meant to mimic the insulin secretion of the natural organ, were diverse and have been reviewed. Allogeneic or xenogeneic cells or cell clusters have been separated from the host's immune system by synthetic biocompatible semipermeable membranes to prevent the need, of the host, for immune-suppressing regimens. The biocompatible polymer used as a barrier and its intrinsic characteristics, the cell immobilization or suspension media, the existence or not of co-immobilized molecules or cells, the number of devices used and the implantation site, were addressed. |
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Authors:
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Ana Isabel Silva; António Norton de Matos; I Gabrielle Brons; Marília Mateus |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Medicinal research reviews Volume: 26 ISSN: 0198-6325 ISO Abbreviation: Med Res Rev Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-06-20 Revised Date: 2007-03-22 |
Medline Journal Info:
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Nlm Unique ID: 8103150 Medline TA: Med Res Rev Country: United States |
Other Details:
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Languages: eng Pagination: 181-222 Citation Subset: IM |
Copyright Information:
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(c) 2005 Wiley Periodicals, Inc. Med Res Rev. |
Affiliation:
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Centro de Engenharia Biológica e Química, Instituto Superior Técnico, Lisboa, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins Alginates / adverse effects Animals Bioartificial Organs* Biocompatible Materials Diabetes Mellitus, Type 1 / surgery* Fibrosis / chemically induced Graft Survival Humans Islets of Langerhans / metabolism Islets of Langerhans Transplantation Membranes, Artificial Pancreas, Artificial* Polylysine / adverse effects Polyvinyl Chloride |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Alginates; 0/Biocompatible Materials; 0/Membranes, Artificial; 25104-18-1/Polylysine; 55963-89-8/XM-50 Amicon; 9002-86-2/Polyvinyl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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