Document Detail

An overview of delayed pressure urticaria with special emphasis on pathogenesis and treatment.
MedLine Citation:
PMID:  19891688     Owner:  NLM     Status:  MEDLINE    
Delayed pressure urticaria (DPU) is a physical urticaria characterized by the development of deep swellings at sites of pressure application on the skin. Etiopathogenesis of DPU is still unknown, although the available evidence suggests the involvement of mast cells through non-immunologic mechanisms and the role of several mediators beyond histamine, such as proinflammatory cytokines. The management of DPU is complex, also considering that prevention is very difficult and DPU frequently coexists with chronic "idiopathic" urticaria. Moreover, H1-antihistamines, which are the mainstay of treatment for common urticaria, usually provide less satisfactory results as compared with other urticarias. Therefore, numerous treatment alternatives have been proposed for severe refractory cases, such as oral or topical corticosteroids and various drugs with anti-inflammatory effects.
Nicoletta Cassano; Valentina Mastrandrea; Michelangelo Vestita; Gino Antonio Vena
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  22 Suppl 1     ISSN:  1529-8019     ISO Abbreviation:  Dermatol Ther     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  S22-6     Citation Subset:  IM    
2nd Dermatology Clinic, Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari, Bari, Italy.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Pressure / adverse effects*
Urticaria / diagnosis,  drug therapy*,  etiology*
Reg. No./Substance:
0/Anti-Inflammatory Agents

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