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An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus.
MedLine Citation:
PMID:  21966294     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The present paper examines the nature and function of brain-derived neurotrophic factor (BDNF) in the hippocampal formation and the consequences of changes in its expression. The paper focuses on literature describing the role of BDNF in hippocampal development and neuroplasticity. BDNF expression is highly sensitive to developmental and environmental factors, and increased BDNF signaling enhances neurogenesis, neurite sprouting, electrophysiological activity, and other processes reflective of a general enhancement of hippocampal function. Such increases in activity may mediate beneficial effects such as enhanced learning and memory. However, the increased activity also comes at a cost: BDNF plasticity renders the hippocampus more vulnerable to hyperexcitability and/or excitotoxic damage. Exercise dramatically increases hippocampal BDNF levels and produces behavioral effects consistent with this phenomenon. In analyzing the literature regarding exercise-induced regulation of BDNF, this paper provides a theoretical model for how the potentially deleterious consequences of BDNF plasticity may be modulated by other endogenous factors. The peptide galanin may play such a role by regulating hippocampal excitability.
Authors:
Patrick S Murray; Philip V Holmes
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Publication Detail:
Type:  Journal Article     Date:  2011-09-28
Journal Detail:
Title:  International journal of peptides     Volume:  2011     ISSN:  1687-9775     ISO Abbreviation:  Int J Pept     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-10     Revised Date:  2012-04-27    
Medline Journal Info:
Nlm Unique ID:  101526297     Medline TA:  Int J Pept     Country:  United States    
Other Details:
Languages:  eng     Pagination:  654085     Citation Subset:  -    
Affiliation:
Neuroscience Program, Biomedical and Health Sciences Institute, The University of Georgia, Athens, GA 30602, USA.
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