| An overlap case of Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-Barré syndrome. | |
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MedLine Citation:
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PMID: 22260976 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 29-year-old female developed diplopia, nasal voice and gait disturbance after an upper respiratory infection. On admission, she presented with bilateral external ophthalmoplegia, slight bilateral facial nerve palsy, dysarthria, dysphagia, cervical and brachial muscle weakness, ataxia and areflexia. She had serum anti-GT1a, anti-GQ1b and anti-galactocerebroside IgG antibodies. She was diagnosed with an overlap case of Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-Barré syndrome. Intravenous immunoglobulin therapy was effective for the ophthalmoplegia and ataxia, but did not improve the bilateral facial nerve palsy and brachial muscle weakness. The facial nerve palsy clearly worsened despite improvement in other symptoms, and therefore high-dose intravenous methylprednisolone therapy was added. The distinct response to treatment may be caused by different activity, production, clearance and reactivity to intravenous immunoglobulin of the autoantibodies. The present case suggests that treatment response and patterns of recovery differ according to the causative anti-ganglioside antibodies. |
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Authors:
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Koji Shinoda; Hiroyuki Murai; Ken-Ichi Shibata; Shoko Samejima; Shuji Kaneto; Nobuyoshi Takashima; Kimihiro Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rinshō shinkeigaku = Clinical neurology Volume: 52 ISSN: 0009-918X ISO Abbreviation: Rinsho Shinkeigaku Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417466 Medline TA: Rinsho Shinkeigaku Country: Japan |
Other Details:
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Languages: eng Pagination: 30-3 Citation Subset: IM |
Affiliation:
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Department of Neurology, Iizuka Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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