| The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. | |
| | |
MedLine Citation:
|
PMID: 20623294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is increasing evidence that cerebrovascular dysfunction plays a role not only in vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk factors and AD impair the structure and function of cerebral blood vessels and associated cells (neurovascular unit), effects mediated by vascular oxidative stress and inflammation. Injury to the neurovascular unit alters cerebral blood flow regulation, depletes vascular reserves, disrupts the blood-brain barrier, and reduces the brain's repair potential, effects that amplify the brain dysfunction and damage exerted by incident ischemia and coexisting neurodegeneration. Clinical-pathological studies support the notion that vascular lesions aggravate the deleterious effects of AD pathology by reducing the threshold for cognitive impairment and accelerating the pace of the dementia. In the absence of mechanism-based approaches to counteract cognitive dysfunction, targeting vascular risk factors and improving cerebrovascular health offers the opportunity to mitigate the impact of one of the most disabling human afflictions. |
| | |
Authors:
|
Costantino Iadecola |
Related Documents
:
|
990124 - Relationship of cerebral oxygen uptake to eeg frequency in isolated canine brain. 6799314 - Changes in brain blood flow associated with deltamethrin-induced choreoathetosis in the... 15887534 - Estimation of coherence between blood flow and spontaneous eeg activity in neonates. 22225264 - Note: signal conditioning of a hot-film anemometer for a periodic flow rate monitoring ... 1192904 - Behavior of calf blood flow in normal subjects and in patients with intermittent claudi... 21409184 - Ten key issues in modern flow chemistry. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-07-11 |
Journal Detail:
|
Title: Acta neuropathologica Volume: 120 ISSN: 1432-0533 ISO Abbreviation: Acta Neuropathol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-07-28 Completed Date: 2010-11-15 Revised Date: 2011-09-13 |
Medline Journal Info:
|
Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: Germany |
Other Details:
|
Languages: eng Pagination: 287-96 Citation Subset: IM |
Affiliation:
|
Division of Neurobiology, Weill Cornell Medical College, New York, NY 10065, USA. coi2001@med.cornell.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
pathology,
physiopathology Animals Brain / blood supply, pathology*, physiopathology Cerebrovascular Circulation / physiology* Cerebrovascular Disorders / pathology*, physiopathology Dementia / pathology*, physiopathology Humans Nerve Degeneration / pathology*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
HL96571/HL/NHLBI NIH HHS; NS37806/NS/NINDS NIH HHS; P01 HL096571-02/HL/NHLBI NIH HHS; R01 NS037853-13/NS/NINDS NIH HHS; R01 NS037853-14/NS/NINDS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Umbilical crease incision for duodenal atresia achieves excellent cosmetic results.
Next Document: Massive retroperitoneal haemorrhage after extracorporeal shock wave lithotripsy (ESWL).