Document Detail

The outcomes of pregnancies following a prenatal diagnosis of fetal exomphalos in Western Australia.
MedLine Citation:
PMID:  19694690     Owner:  NLM     Status:  MEDLINE    
AIMS: To review the perinatal outcomes for prenatally diagnosed exomphalos from a single geographical region. METHODS: Retrospective review of cases of prenatally identified exomphalos in the state of Western Australia in the ten-year period 1998-2007 using the medical databases of the sole tertiary obstetric and paediatric hospitals. RESULTS: Ninety-four cases of prenatally identified exomphalos comprise this consecutive case series. Culture-proven karyotypic abnormalities occurred in 40 (42.6%) fetuses. No karyotypically abnormal fetus survived the neonatal period, with 33 of 40 (82.5%) pregnancies interrupted, five of 40 (12.5%) resulting in fetal demise and two (5%) neonatal deaths. For the 49 (52.1%) fetuses with a normal karyotype, 26 (53.1%) had associated abnormalities with termination occurring in 22 (84.6%). Prenatally isolated exomphalos was present in 23 cases (24.5%), with live birth in 15 cases (30.6% of euploid fetuses). Fourteen (93.3%) of the liveborn prenatally isolated exomphalos cases survived with no postoperative deaths, although four (28.5%) had significant abnormalities detected postdelivery and most have experienced childhood morbidity. CONCLUSIONS: In the the majority of cases of prenatally detected exomphalos the pregnancy was interrupted secondary to chromosomal or structural abnormalities. In only 10.6% of prenatally recognised fetuses with exomphalos was the disorder truly isolated with neonatal survival occurring.
Nick Calvert; Sara Damiani; Julian Sunario; Caroline Bower; Jan E Dickinson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  49     ISSN:  1479-828X     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  371-5     Citation Subset:  IM    
School of Women's and Infants' Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Western Australia, Australia.
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MeSH Terms
Abnormalities, Multiple / epidemiology,  genetics,  ultrasonography*
Chromosome Aberrations
Hernia, Umbilical / epidemiology,  genetics,  ultrasonography*
Infant, Newborn
Pregnancy Outcome
Prenatal Diagnosis / methods*
Retrospective Studies
Risk Factors
Survival Analysis
Ultrasonography, Prenatal
Western Australia / epidemiology

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