| The outcomes of lung transplantation in patients with bronchiectasis and antibody deficiency. | |
| | |
MedLine Citation:
|
PMID: 16210124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Lung transplantation is an established treatment for end-stage bronchiectasis. A proportion of patients with bronchiectasis have an associated antibody deficiency. This group benefits from immunoglobulin replacement therapy, but the outcome of lung transplantation is not known. METHODS: We conducted a retrospective observational study of all who received a transplant for bronchiectasis at our unit. We compared the survival after transplant, number of infective and rejection episodes, and the change in forced expiratory volume in 1 second (FEV1). RESULTS: Five of the 37 patients identified with bronchiectasis had an antibody deficiency that required immunoglobulin replacement therapy. Actuarial survival was similar in the 2 groups, being 81% at 12 months in the Bronchiectasis Group and 80% in the Antibody Deficiency Group. The FEV1 at 12 months after transplantation was similar in each group, with a predicted mean +/- SD FEV1 of 83.7% +/- 24.2% in those with bronchiectasis and 83.0% +/- 30.4% in those with antibody deficiency as well. The infection and rejection rates in the first year after transplantation were lower in the Antibody Deficiency Group. Infection episodes per 100 patient-days for bronchiectasis alone were 0.90 vs 0.53 and rejection episodes per 100 patient-days were 0.59 vs 0.24. CONCLUSIONS: There was no evidence that transplant recipients with bronchiectasis and antibody deficiency have a worse prognosis than those with bronchiectasis alone. |
| | |
Authors:
|
James A Nathan; Linda D Sharples; Andrew R Exley; Pasupathy Sivasothy; John Wallwork |
Related Documents
:
|
16386554 - Impact of hla antibodies on transplant glomerulopathy. 9408684 - Igm antibodies in renal transplantation. 15280674 - Consensus opinion from the antibody working group on the diagnosis, reporting, and risk... 15155164 - Daclizumab induction in solid organ transplantation. 2305464 - Causes of graft loss beyond two years in the cyclosporine era. 9580814 - Post-kala-azar dermal leishmaniasis with mucosal involvement in a kidney transplant rec... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 24 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-10-07 Completed Date: 2006-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
|
Languages: eng Pagination: 1517-21 Citation Subset: IM |
Affiliation:
|
Papworth Hospital NHS Trust, Papworth Everard, Cambridge, United Kingdom. janathan@btinternet.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antifungal Agents / therapeutic use Antiviral Agents / therapeutic use Bronchiectasis / complications, surgery* Chemoprevention Cytomegalovirus Infections / etiology Female Forced Expiratory Volume Graft Rejection / etiology, prevention & control Heart Transplantation Humans Immunoglobulins, Intravenous / therapeutic use Immunologic Deficiency Syndromes / complications, surgery* Immunosuppressive Agents / therapeutic use Infection / etiology, therapy Lung Transplantation* Male Middle Aged Retrospective Studies Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Antiviral Agents; 0/Immunoglobulins, Intravenous; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Percutaneous tracheostomy after mechanical ventricular assist device implantation.
Next Document: Gastroesophageal reflux (symptomatic and silent): a potentially significant problem in patients with...