Document Detail

The outcome of twin reversed arterial perfusion sequence diagnosed in the first trimester.
MedLine Citation:
PMID:  20522408     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to document the mortality of twin reversed arterial perfusion (TRAP) sequence from the first trimester to planned intervention at 16-18 weeks. STUDY DESIGN: A retrospective review was performed of the outcome of monochorionic twin pregnancies diagnosed with twin reversed arterial perfusion sequence in the first trimester. RESULTS: Twenty-six pregnancies were diagnosed with twin reversed arterial perfusion sequence in the first trimester: 2 opted for termination of pregnancy and 24 opted for prophylactic intervention to arrest the reversed flow, which was planned at 16-18 weeks. In 8 of 24 (33%) pregnancies, spontaneous death of the pump twin occurred between diagnosis and planned intervention. In 5 of 24 (21%), there was a spontaneous arrest of flow; whereas, in 11 (46%) there was persistent flow toward the acardiac twin at 16-18 weeks. CONCLUSION: Twin reversed arterial perfusion carries a high mortality between the first and early second trimester.
Liesbeth Lewi; Catalina Valencia; Esperanza Gonzalez; Jan Deprest; Kypros H Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-03
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010. Published by Mosby, Inc.
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
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MeSH Terms
Abortion, Induced / statistics & numerical data
Abortion, Spontaneous / epidemiology
Fetal Death / epidemiology
Fetofetal Transfusion / diagnosis*,  mortality*,  surgery
Laser Coagulation
Live Birth / epidemiology
Pregnancy Trimester, First*
Retrospective Studies
Umbilical Cord / surgery,  ultrasonography

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