Document Detail

The outcome of patients with transient ischemic attacks and stroke treated with anticoagulants.
MedLine Citation:
PMID:  7457205     Owner:  NLM     Status:  MEDLINE    
Long-term anticoagulant treatment was given to 25 patients with transient ischemic attacks (TIA) and 49 stroke patients with reversible ischemic neurological deficit or cerebral embolism. Another 16 TIA patients were observed without anticoagulant treatment. Life table analyses, comparing the observed with the expected frequency, revealed increased mortality in the TIA patients irrespective of whether or not they had received anticoagulants. The stroke patients treated with anticoagulants also had a higher mortality than expected. On the other hand, the incidence of subsequent stroke was not higher than expected in the TIA and stroke patients treated with anticoagulants, while it was significantly increased in the TIA patients not treated with anticoagulants. Thus, the risk of stroke, but not the risk of death, was normalized by the anticoagulant treatment. Unacceptably serious bleeding complications were seen in the group of stroke patients with anticoagulant treatment. Bleeding complications, in both TIA and stroke patients, seemed to be related to lengthy treatment, high blood pressure on admission or insufficient patient compliance.
A Terént; B Andersson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  208     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  359-65     Citation Subset:  IM    
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MeSH Terms
Anticoagulants / adverse effects,  therapeutic use*
Cerebrovascular Disorders / drug therapy*,  mortality
Hemorrhage / chemically induced
Ischemic Attack, Transient / drug therapy*,  mortality
Middle Aged
Time Factors
Reg. No./Substance:

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