| The outcome in myasthenia gravis patients--an eight-year follow-up after finishing immunoabsorption therapy. | |
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MedLine Citation:
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PMID: 11515619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight years ago four patients suffering from myasthenia gravis (MG) type C and E according to Compston with failed drug therapy were treated three times (one patient 11 times) by protein A immunoabsorption (Immunosorba, Excorim, Fresenius Hemocare GmbH, StWendel, Germany). No further immunoabsorption treatments have been carried out. In addition, three patients were given a thymectomy. The present status of the patients was checked six and eight years thereafter. We could see a beneficial effect in all MG patients. The patients are fit for work; all have an improved Besinger index. The patients were used as their own controls. A higher anti-AChR-ab level six years after protein A immunoabsorption than at the beginning was seen in all patients combined with a less serious MG. In addition, their immunomodulation could be induced as seen in lymphocyte and inflammatory protein changes during the first 36 days after beginning immunoabsorption treatment. A larger population has to be investigated to verify these results. |
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Authors:
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J M Schneidewind; U K Zettl; R E Winkler; W Ramlow; M Tiess; A Michelsen; G Hebestreit; H Prophet; W Pätow; R Benecke |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Volume: 24 ISSN: 1473-0502 ISO Abbreviation: Transfus. Apher. Sci. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-08-22 Completed Date: 2001-12-20 Revised Date: 2006-06-07 |
Medline Journal Info:
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Nlm Unique ID: 101095653 Medline TA: Transfus Apher Sci Country: England |
Other Details:
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Languages: eng Pagination: 95-8 Citation Subset: T |
Affiliation:
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Dialyse-Germeinschaft Nord eV, Rostock, Germany. tiess@dialysis-north.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies / blood Blood Component Removal / methods Female Follow-Up Studies Humans Immunosorbent Techniques Male Middle Aged Muscle, Skeletal / immunology Myasthenia Gravis / therapy* Receptors, Cholinergic / immunology Salvage Therapy Staphylococcal Protein A / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Receptors, Cholinergic; 0/Staphylococcal Protein A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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