| The outcome of absence epilepsy: a meta-analysis. | |
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MedLine Citation:
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PMID: 8797483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a meta-analysis of studies on absence epilepsy (AE) to ascertain whether the outcome of this well-defined type of epilepsy can be stated unequivocally. Using the Index Medicus and Medline CD+, we identified 1,619 publications. After applying the criteria of the International League against Epilepsy (ILAE) for AE, 26 publications on 23 study cohorts with a total of 2,303 patients were included. Remission rates ranged from 0.21 to 0.89; they differed substantially due to heterogeneity between the studies in inclusion criteria, methods, follow-up length, and outcome definitions. One half of the patients developed generalized tonic-clonic seizures (TCS) in the course of the disease. The proportion seizure free was 0.78 for patients with absence seizures (AS) only, and 0.35 for those who developed TCS. The outcome of AE may be worse than previously stated due to the considerable proportion of patients developing TCS in the course of their disease. Early prediction of outcome in patients who present with AS cannot be provided with certainty. |
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Authors:
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P A Bouma; R G Westendorp; J G van Dijk; A C Peters; O F Brouwer |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Neurology Volume: 47 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-22 Completed Date: 1996-11-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 802-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Leiden University Hospital, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Child Epilepsy, Absence / physiopathology* Female Humans Male Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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