Document Detail

An outbreak of vitamin D deficiency rickets in a susceptible population.
MedLine Citation:
PMID:  574626     Owner:  NLM     Status:  MEDLINE    
Nutritional, racial, cultural, and environmental factors have combined to produce a resurgence of vitamin D deficiency rickets in urban Philadelphia. Between January 1974 and June 1978, 24 cases were diagnosed at the Children's Hospital of Philadelphia. Patients' ages ranged from 4 to 58 months. Presenting complaints included seizures, swollen wrists, pathologic fractures, and developmental regression. Sixteen patients were below the third percentile for length and weight. Laboratory results indicated vitamin D deficiency in nursing mothers as well as in infants. All infants had been breast-fed and all were black. Ingestion of vitamin D was limited by exclusion of meat and/or dairy products in 21, and no infants had consistently taken supplemental vitamins. Nineteen were members of Muslim or Seventh Day Adventist faiths. Endogenous synthesis of vitamin D was limited by dark skin, by dressing in long garments with hoods and veils, and by air pollution in a densely populated northern city. The return to a more "natural" diet, free of food additives, has been accompanied by the return of a classic disease of industrial society. Effective management required patience and respect for religious convictions. With treatment, there was correction of chemical and skeletal abnormalities, but few patients showed catch-up growth.
S Bachrach; J Fisher; J S Parks
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  64     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  871-7     Citation Subset:  AIM; IM    
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MeSH Terms
African Americans
Breast Feeding
Child, Preschool
Disease Outbreaks*
Disease Susceptibility
Food Habits
Rickets / diagnosis,  epidemiology*,  etiology
Urban Population
Vitamin D / therapeutic use
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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