Document Detail

An outbreak of necrotizing enterocolitis associated with norovirus genotype GII.3.
MedLine Citation:
PMID:  20589982     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Necrotizing enterocolitis (NEC) is an acute abdominal emergency of unknown etiology predominantly affecting preterm infants. We describe a cluster of NEC in a level III NICU involving 15 infants over a6-month period. Cohorting and stringent infection control measures were associated with termination of the cluster. A case-control study was used to investigate potential risk factors associated with development of NEC. METHODS: Stool samples were collected from 55 infants (10 of 15 NEC and 45 non-NEC controls). Enteric pathogens were identified by culture and/or molecular diagnostic techniques. For the case-control study, controls were selected from admitted neonates during the same time and in the preceding 6-month period, matched for gestation and birthweight. RESULTS: Forty percent (4/10) of NEC infants had norovirus RNA detected compared with 9% (4/45) of non-NEC infants (OR: 6.83, 95% CI: 1.3-34.9,P = 0.021). A lower rate of prolonged rupture of membranes and a higher rate of maternal smoking was also observed in NEC infants than in controls. No significant differences in incidences of chorioamnionitis, intrapartum antibiotics,volume of feedings, time of first formula feeding, and rates of patent ductus arteriosus or intrauterine growth retardation were detected. CONCLUSIONS: Infants who developed NEC had an increased incidence of norovirus detection in their stool following diagnosis. This further strengthens the case for an etiologic role of norovirus in the pathogenesis of NEC.
Rhonda L Stuart; Kenneth Tan; Jackie E Mahar; Carl D Kirkwood; C Andrew Ramsden; Nick Andrianopoulos; Damien Jolley; Kaye Bawden; Richard Doherty; Despina Kotsanas; Jennifer Bradford; Jim P Buttery
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  29     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  IM    
Department of Infectious Diseases, Monash Medical Centre, Clayton. Victoria 3168, Australia.
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MeSH Terms
Caliciviridae Infections / epidemiology*,  virology*
Case-Control Studies
Cross Infection / epidemiology,  virology
Disease Outbreaks*
Enterocolitis, Necrotizing / epidemiology*,  virology*
Feces / virology
Infant, Newborn
Infection Control / methods
Intensive Care Units, Neonatal
Norovirus / classification*,  genetics*,  isolation & purification
RNA, Viral / isolation & purification
Risk Factors
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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