Document Detail

An outbreak of multidrug-resistant Pseudomonas aeruginosa infection associated with contamination of bronchoscopes and an endoscope washer-disinfector.
MedLine Citation:
PMID:  11023719     Owner:  NLM     Status:  MEDLINE    
Over a two-month period, two distinct types of Pseudomonas aeruginosa resistant to ceftazidime and azlocillin were isolated from bronchial specimens of ITU patients who had been previously bronchoscoped. The source of the outbreak was probably a faulty contaminated bronchoscope washer-disinfector which had been purchased a year earlier but not properly maintained. This paper describes the outbreak, the identification and elimination of the source, and the steps taken to prevent recurrence. Several automated, closed washer-disinfectors had been bought by the hospital in response to health and safety concerns about glutaraldehyde disinfection toxicity, but the operation and maintenance of these machines had not been supervised. Several other washer-disinfectors were also found to be faulty. The potential hazards of automated endoscope washer-disinfectors and the importance of controlled professional maintenance, servicing and training is discussed.
S Schelenz; G French
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of hospital infection     Volume:  46     ISSN:  0195-6701     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
Department of Infection, Guy's King's and St Thomas' School of Medicine, St Thomas' Hospital Campus, London, SE17EH, UK.
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MeSH Terms
Azlocillin / pharmacology
Bronchoscopes / microbiology*
Ceftazidime / pharmacology
Cross Infection / epidemiology*,  prevention & control
Disease Outbreaks*
Disinfection / methods
Drug Resistance, Multiple*
Equipment Contamination*
London / epidemiology
Polymerase Chain Reaction
Pseudomonas Infections / epidemiology*,  prevention & control
Pseudomonas aeruginosa / drug effects,  genetics,  isolation & purification
Reg. No./Substance:
37091-66-0/Azlocillin; 78439-06-2/Ceftazidime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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