Document Detail


An outbreak of hospital-acquired Pseudomonas aeruginosa infection caused by contaminated bottled water in intensive care units.
MedLine Citation:
PMID:  18294245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes an outbreak of Pseudomonas aeruginosa infections caused by contaminated bottled still water (BSW) in six intensive care units (ICUs) of a German university hospital. Clinical and environmental samples from these units were cultured and genotyped by amplified fragment-length polymorphism and pulsed-field gel electrophoresis analysis. Microbiological results were reviewed on a weekly basis to determine the number of P. aeruginosa infections and colonisations of ICU patients. Clinical specimens from 19 ICU patients--15 infections and four colonisations--yielded the same strain of P. aeruginosa. Furthermore, four of 103 environmental samples also yielded P. aeruginosa. However, only a P. aeruginosa strain isolated from unopened BSW was genetically identical to the P. aeruginosa strain isolated from the patients. In the 42-week period before the outbreak, the mean weekly number of new ICU patients infected or colonised with P. aeruginosa was 46.9 (95% CI 40.7-53.1)/1000 bed-days. During the 6-week period of the outbreak, the weekly number of new patients with P. aeruginosa was 88.9 (95% CI 54.3-122.2)/1000 bed-days. This number returned to the previous level after removal of the BSW. Thus, the microbiological and epidemiological findings revealed that the outbreak was related to BSW contaminated with P. aeruginosa. It was concluded that all untested BSW should be removed from ICUs.
Authors:
T Eckmanns; M Oppert; M Martin; R Amorosa; I Zuschneid; U Frei; H Rüden; K Weist
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Publication Detail:
Type:  Journal Article     Date:  2008-02-22
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  14     ISSN:  1198-743X     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-10     Completed Date:  2008-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  454-8     Citation Subset:  IM    
Affiliation:
Robert Koch Institute, Berlin, Germany. eckmannst@rki.de
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MeSH Terms
Descriptor/Qualifier:
Cross Infection / epidemiology*
Disease Outbreaks*
Germany / epidemiology
Humans
Intensive Care Units*
Pseudomonas Infections / epidemiology*
Pseudomonas aeruginosa / isolation & purification*
Water Microbiology*
Water Supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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