Document Detail

An outbreak of hepatic veno-occlusive disease in north-western Afghanistan.
MedLine Citation:
PMID:  59848     Owner:  NLM     Status:  MEDLINE    
Following a 2-year period of severe drought a very large number of patients with massive ascites and emaciation were observed in north-western Afghanistan. Clinicopathological study showed that these were typical cases of hepatic veno-occlusive disease. The outbreak was caused by consumption of bread made from wheat contiminated with seeds of Heliotropium plants, which were shown to contain pyrrolizidine alkaloids. Examination of 7200 inhabitants from the affected villages showed evidence of liver disease in 22.6%. Clinical improvement was observed in thirteen cases after 3 to 9 months of supportive hospital treatment, and in three cases liver biopsies showed almost complete disappearance of initial abnormalities.
O Mohabbat; M S Younos; A A Merzad; R N Srivastava; G G Sediq; G N Aram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  269-71     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Disease Outbreaks*
Food Contamination
Liver / blood supply*
Middle Aged
Plants, Toxic*
Pyrrolizidine Alkaloids / poisoning*
Thrombophlebitis / chemically induced*
Reg. No./Substance:
0/Pyrrolizidine Alkaloids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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