Document Detail


An outbreak due to echovirus type 30 in a neonatal unit in France in 1997: usefulness of PCR diagnosis.
MedLine Citation:
PMID:  10462641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between February and August 1997, 53 patients with enterovirus meningitis were hospitalized in Clermont-Ferrand, France. All but one were children. Echovirus type 30 was involved in 70% of cases with identified serotype. The outbreak ceased on August 8. Two months later, a neonate was admitted to the neonatal unit with an echovirus type 30 meningitis thought to be acquired at delivery. Twenty days later a nosocomial outbreak of echovirus type 30 involving five neonates occurred. Two of them presented with meningitis and two with febrile seizure; One was asymptomatic. The retrospective examination of the maternal sera in a neutralization test, using the index case strain as a source of antigen, showed that none of the neonates was passively immunized before hospitalization. The use of genome detection in cerebrospinal fluid allowed rapid diagnosis and infection was contained by re-inforcing hygiene measures. Prospective examination of stools in the neonatal and paediatric units showed no further occurrences of the disease. No sporadic case was observed in the general population. Hence, nosocomial infections can occur a long time after an outbreak in the general population; rapid diagnosis with molecular tools is useful both for a definite diagnosis in patients already hospitalized, and to act as a rapid alert, even in intervals between seasonal outbreaks.
Authors:
M Chambon; J L Bailly; A Béguet; C Henquell; C Archimbaud; J Gaulme; A Labbé; G Malpuech; H Peigue-Lafeuille
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of hospital infection     Volume:  43     ISSN:  0195-6701     ISO Abbreviation:  J. Hosp. Infect.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-10     Completed Date:  1999-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007166     Medline TA:  J Hosp Infect     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Copyright Information:
Copyright 1999 The Hospital Infection Society.
Affiliation:
Departments of Paediatrics and Clinical Virology, Centre Hospitalier Universitaire, Clermont-Ferrand, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Viral / blood
Cross Infection / blood,  cerebrospinal fluid,  diagnosis,  epidemiology*
Disease Outbreaks*
Echovirus Infections / blood,  cerebrospinal fluid,  diagnosis,  epidemiology*
Enterovirus B, Human / classification,  genetics,  isolation & purification*
Female
France / epidemiology
Humans
Infant, Newborn
Male
Meningitis, Viral / blood,  cerebrospinal fluid,  diagnosis,  epidemiology*
Polymerase Chain Reaction* / methods
Prospective Studies
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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