Document Detail

An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: a clinicopathological study.
MedLine Citation:
PMID:  1890547     Owner:  NLM     Status:  MEDLINE    
An outbreak of food poisoning resulting in 13 deaths in children occurred in Malaysia during the Chinese Festival of the Nine-Emperor Gods in 1988. The offending food was a Chinese noodle called 'Loh See Fun' (LSF). The source was traced to a factory where a banned food preservative was added to make the LSF. The food poisoning was attributable to aflatoxins and boric acid. The clinical features included vomiting, pyrexia, diarrhoea, abdominal pain, anorexia, giddiness, seizures, and eventual coma. Initially, many presented with a Reye-like syndrome. Eleven post-mortem examinations were performed. The pathological findings included extensive coagulative necrosis of the liver with proliferative 'ductal/ductular metaplasia of the hepatocytes'. Giant cell formation, central vein sclerosis, bile stasis, and steatosis were also noted. There was presence of acute tubular necrosis, superficial upper gastrointestinal erosions, and ensuing encephalopathy. The eventual cause of death is acute hepatic and renal failure.
T C Chao; S M Maxwell; S Y Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  164     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-11     Completed Date:  1991-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Institute of Science and Forensic Medicine, Singapore.
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MeSH Terms
Aflatoxins / analysis,  poisoning*
Boric Acids / poisoning*
Child, Preschool
Diagnosis, Differential
Disease Outbreaks*
Kidney / pathology
Liver / pathology
Metaplasia / pathology
Middle Aged
Mycotoxicosis / epidemiology,  pathology*
Necrosis / pathology
Reye Syndrome / diagnosis
Reg. No./Substance:
0/Aflatoxins; 0/Boric Acids; 11113-50-1/boric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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