| An outbreak of acute aflatoxicosis on a chinchilla (Chinchilla lanigera) farm in Argentina. | |
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MedLine Citation:
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PMID: 18987247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chinchillas (Chinehilla lanigera) are known to be very sensitive to aflatoxins, and often a large number of animals die if toxicosis occurs. An outbreak of acute aflatoxicosis on a chinchilla farm in Argentina is described in the present study. A commercial feed suspected of causing the death of 200 animals was sampled. Livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics via necropsy and histopathology. Aflatoxins B(1), B(2), G(1), and G(2) were determined, by thin layer chromatography, to be in the feed. Macroscopic inspection of livers revealed general enlargement, pale-yellowish coloration, hypertrophy, rounded borders, and increased friability. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe, diffuse cytoplasmic vacuolation of hepatocytes. Sudan III staining confirmed the presence of lipid within the vacuoles. The feed was positive for aflatoxin B(1) in quantities that exceeded the recommended levels. Histologic lesions were typical of aflatoxin intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks of toxicosis, to improve management practices, and to diminish exposure risk of animals and humans to these harmful toxins. |
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Authors:
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María L González Pereyra; Eulogio C Q Carvalho; Jorge L Tissera; Kelly M Keller; Carina E Magnoli; Carlos A R Rosa; Ana M Dalcero; Lilia R Cavaglieri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc Volume: 20 ISSN: 1040-6387 ISO Abbreviation: J. Vet. Diagn. Invest. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-06 Completed Date: 2008-12-31 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9011490 Medline TA: J Vet Diagn Invest Country: United States |
Other Details:
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Languages: eng Pagination: 853-6 Citation Subset: IM |
Affiliation:
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Departamento de Microbiología e Inmunología, Universidad Nacional de Río Cuarto, Ruta 36 Km. 601, Río Cuarto, Córdoba, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxins
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analysis,
toxicity* Animal Feed / analysis* Animals Animals, Domestic Argentina Chinchilla* Disease Outbreaks / veterinary* Foodborne Diseases / pathology, veterinary* Hepatocytes / pathology Liver / pathology* Mycotoxicosis / pathology, veterinary* Vacuoles / pathology |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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