Document Detail

An outbreak of Salmonella Paratyphi A in a boarding school: a community-acquired enteric fever and carriage investigation.
MedLine Citation:
PMID:  20800009     Owner:  NLM     Status:  MEDLINE    
Salmonella Paratyphi A (SPA) is rapidly becoming a common cause of enteric fever in South East Asia. A large outbreak of SPA occurred in a boarding middle school in China in 2004. There were 394 suspected cases; 95·5% were students. The highest incidence was in the youngest children (7th grade). Forty-four of 151 (29%) blood cultures and 4/54 (7·4%) rectal swabs were positive for SPA; three were from kitchen workers. The geometric mean levels of serum IgG anti-lipopolysaccharide (anti-LPS) from patients was higher than from healthy individuals [35·25 vs. 5·20 ELISA units (EU), P<0·001]. A kitchen worker with a positive rectal swab, negative blood culture and a high level of serum IgG anti-LPS (529·65 EU), was identified as a possible SPA carrier. No SPA was isolated from water or food samples. A survey of students' habits indicated drinking unboiled water as being the main reason for contracting the disease. Hand washing was the second most important factor. A food handler with possible SPA carriage could also have been a risk factor. Attention to maintaining a safe water supply, enhancing food-handler hygiene and proper hand washing can help to prevent similar outbreaks in the future.
H H Yang; J Gong; J Zhang; M L Wang; J Yang; G Z Wu; W L Quan; H M Gong; S C Szu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-08-27
Journal Detail:
Title:  Epidemiology and infection     Volume:  138     ISSN:  1469-4409     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2010-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1765-74     Citation Subset:  IM    
Guangxi Center for Disease Control and Prevention, Nanning, Guangxi, China.
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MeSH Terms
Antibodies, Bacterial / blood
Asia, Southeastern
Blood / microbiology
Carrier State / epidemiology*,  microbiology
China / epidemiology
Community-Acquired Infections / epidemiology*,  microbiology
Disease Outbreaks*
Enzyme-Linked Immunosorbent Assay
Feeding Behavior
Immunoglobulin G / blood
Lipopolysaccharides / immunology
Middle Aged
Paratyphoid Fever / epidemiology*,  microbiology
Rectum / microbiology
Salmonella paratyphi A / isolation & purification*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G; 0/Lipopolysaccharides

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