Document Detail

The ototoxic effect of boric acid solutions applied into the middle ear of guinea pigs.
MedLine Citation:
PMID:  18795310     Owner:  NLM     Status:  MEDLINE    
This study analyzed the ototoxic effects of boric acid solutions. Boric acid solutions have been used as otologic preparations for many years. Boric acid is commonly found in solutions prepared with alcohol or distilled water but can also be found in a powder form. These preparations are used for both their antiseptic and acidic qualities in external and middle ear infections. We investigated the ototoxic effect of boric acid solutions on guinea pigs. We are unaware of any similar, previously published study of this subject in English. The study was conducted on 28 young albino guinea pigs. Prior to application of the boric acid solution under general anesthesia, an Auditory Brainstem Response (ABRs) test was applied to the right ear of the guinea pigs. Following the test, a perforation was created on the tympanic membrane of the right ear of each guinea pig and small gelfoam pieces were inserted into the perforated area. Test solutions were administered to the middle ear for 10 days by means of a transcanal route. Fifteen days after inserting the gelfoams in all of the guinea pigs, we anasthesized the guinea pigs and removed the gelfoams from the perforated region of the ear and then performed an ABRs on each guinea pig. The ABRs were within the normal range before the applications. After the application, no significant changes were detected in the ABRs thresholds in neither the saline group nor the group administered boric acid and distilled water solution; however, significant changes were detected in the ABRs thresholds of the Gentamicine and boric acid and alcohol solution groups. We believe that a 4% boric acid solution prepared with distilled water can be a more reliable preparation than a 4% boric acid solution prepared with alcohol.
Sedat Oztürkcan; Riza Dündar; Hüseyin Katilmis; Ali Ekber Ilknur; Sinem Aktaş; Senem Haciömeroğlu
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-09-16
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  266     ISSN:  1434-4726     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  663-7     Citation Subset:  IM    
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, Izmir, Turkey.
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MeSH Terms
Auditory Threshold
Boric Acids / administration & dosage,  adverse effects*
Ear Diseases / chemically induced*,  diagnosis
Ear, Middle / drug effects*
Evoked Potentials, Auditory, Brain Stem
Guinea Pigs
Insecticides / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Boric Acids; 0/Insecticides; 0/Solutions; 11113-50-1/boric acid

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