Document Detail


Is osteoarthritis a systemic disorder of bone?
MedLine Citation:
PMID:  14872487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the osteologic findings associated with osteoarthritis (OA) of a variety of joints. METHODS: We performed visual examination of 563 skeletons of which >/=80% of the skeleton was available, from an archaeologic site in England. The surfaces and margins of several different joints (shoulders, elbows, wrists, hips, hands, knees, and ankles) were studied for evidence of eburnation and osteophytes, respectively, and the entire skeleton was examined for evidence of generalized enthesophyte formation. Associations between changes in different joint sites and between enthesophyte formation and evidence of OA were sought. RESULTS: Eburnation and osteophyte formation at the hand, hip, and knee were strongly associated with eburnation and osteophytes at other joint sites not commonly thought to be prone to OA, including the elbow and wrist. Only the ankle was rarely involved. There was also a strong relationship between both bone eburnation and osteophytes and generalized enthesophyte formation. These findings remained statistically significant after adjustment for the age, sex, and historical period of the skeletons. CONCLUSION: Our findings indicate that skeletal OA is more widespread in the body than is apparent from clinical studies and are consistent with other data suggesting that OA is a disease that is primarily dependent on systemic predisposition to a particular type of bone response to mechanical stress.
Authors:
Juliet Rogers; Lee Shepstone; Paul Dieppe
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  50     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-11     Completed Date:  2004-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  AIM; IM    
Affiliation:
University of East Anglia, Norwich, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Diseases / complications,  history,  pathology*
Bone and Bones / pathology*
England
Female
History, 15th Century
History, Ancient
History, Medieval
Humans
Joints / pathology*
Male
Middle Aged
Ossification, Heterotopic / history,  pathology*
Osteoarthritis / etiology,  history,  pathology*
Paleopathology
Stress, Mechanical
Comments/Corrections
Comment In:
Arthritis Rheum. 2004 Feb;50(2):341-4   [PMID:  14872473 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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