| An oscillator theory of motor unit recruitment. | |
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MedLine Citation:
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PMID: 17994248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phenomenon of systematic recruitment of motor units with increasing demand load is usually explained by the size principle. Though this principle successfully explains the gain-related aspects of muscle force generation, it does not address the need for desynchronization of motor unit activities in order to produce a smooth tension profile at the level of whole muscle, while individual muscle fibers are "twitching." We propose an oscillator model of motor neurons in which a pool of motor neurons fires a bundle of muscle fibers. Although individual muscle fibers have a complicated tension profile, the tension produced by the entire bundle is regulated and follows a command signal accurately. This is shown to be possible because of uncorrelated activity produced by local inhibitory connections among motor neurons. Connections that produce synchronized oscillations result in uncontrolled contractions of the muscle. These results seem to suggest that while synchronized activity indicates pathology and disease, desynchronized activity is the precondition for normal muscle function. Physiological evidence for the proposed theory of motor unit synchronization is presented. |
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Authors:
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P S Prashanth; V S Chakravarthy |
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Publication Detail:
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Type: Journal Article Date: 2007-11-10 |
Journal Detail:
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Title: Biological cybernetics Volume: 97 ISSN: 0340-1200 ISO Abbreviation: Biol Cybern Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-03-13 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502533 Medline TA: Biol Cybern Country: Germany |
Other Details:
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Languages: eng Pagination: 351-61 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering, Indian Institute of Technology, Chennai 600 036, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks* Electric Stimulation Humans Models, Biological Models, Neurological* Motor Neurons / physiology* Muscle, Skeletal / cytology* Neural Inhibition / physiology*, radiation effects |
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